Tank bottom high shear emulsifier

Description :

Tank bottom high shear uniform non layered emulsifier

High speed fixed rotor precision clearance, linear speed exceeding 20m/s, can refine material particle size to below 1 μ m, with uniform and narrow particle size distribution, greatly improving drug stability and bioavailability, solving industry pain points such as material stratification, precipitation, and uneven mixing, and adapting to homogenization processes for various insoluble drugs, suspensions, and creams.

The equipment is made of sanitary grade 304/SUS316L stainless steel, with polished inner surfaces, no hidden materials, easy to clean, and can meet the requirements of CIP online cleaning and SIP online sterilization, in compliance with GMP clean production standards. Compact structure, easy installation, stable operation, high shear efficiency, can significantly shorten production cycle, improve product uniformity and stability, suitable for process scenarios such as drug preparation, paste emulsification, suspension preparation, colloid homogenization, etc.

Flexible installation and good adaptability

The bottom mounted structure does not occupy the space on the top of the tank, and is suitable for tanks with existing mixing, manholes, and pipelines on the top of the tank. It can be seamlessly integrated with various reaction vessels and batching tanks, supporting tanks of different volumes from 5L to 10000L. It is suitable for high viscosity materials and can be customized for vacuum, pressure, and explosion-proof conditions to meet the diverse pharmaceutical production needs.

Working principle: When the equipment is running, the rotor rotates at high speed to generate negative pressure suction, which sucks the material at the bottom of the tank into the gap between the stator and rotor; The material is instantly crushed to a particle size of less than 1 μ m under the action of strong shear, centrifugal extrusion, and liquid layer friction, and then sprayed out at high speed through the stator slot, forming a circulation inside the tank and achieving homogenization of the entire tank.

Adaptation system: It can be integrated with tank top mixing and internal and external circulation pipelines to form a collaborative system of "bottom homogenization+top mixing", which is suitable for high viscosity materials and multiphase mixing processes.

Homogeneous and efficient: The high shear rotor can evenly disperse active ingredients and excipients, with narrow particle size distribution, improving the stability and bioavailability of the drug solution, and is suitable for the production of injections, oral liquids, ointments, vaccines, and other products.

Flexible installation: The bottom mounted design does not occupy the space on the top of the tank, avoiding material splashing and adapting to low liquid levels and inconvenient installation conditions on the top of the tank. It can be seamlessly integrated with existing reaction vessels and batching tanks.

Stable and reliable: The mechanical seal system is suitable for high temperatures, organic solvents, and materials that are prone to crystallization. It has an IP55 protection level and supports 24-hour continuous operation, reducing maintenance costs.

Multi scenario adaptation: It can handle various types of pharmaceutical materials such as water injections, syrups, creams, suspensions, biologics, etc., and is compatible with high, medium, and low viscosity working conditions.

Tank bottom high shear uniform non layered emulsifier

Aseptic preparations: Homogenization and dispersion of injection, infusion, and vaccine suspensions to ensure uniform composition and stable particle size.

Oral preparations: Emulsified mixtures of syrup, oral liquid, and suspension to enhance taste and absorption.

• External preparation: Homogeneous emulsification of ointment, cream and gel to ensure fine quality and uniform composition.

Biopharmaceuticals: Cell lysis, protein suspension, enzyme preparation mixing, suitable for sterile and high cleanliness requirements.

• Traditional Chinese medicine preparations: dispersion and homogenization of traditional Chinese medicine extracts and compound preparations to enhance the consistency of drug efficacy

Provide customized selection services, accurately matching models based on tank volume, material characteristics, and process requirements; Covering the entire process of on-site installation and debugging, operator training, and CIP/SIP verification; Provide complete equipment qualification documents, testing reports, after-sales spare parts supply, and lifelong maintenance services to safeguard the quality of drug production

AfterSalesService :